We investigate two main sources of information inaccuracies in demand information sharing along the supply chain. Firstly, we perform a systematic literature review on inaccuracy in demand information sharing and its impact on supply chain dynamics. Secondly, we model several SC settings using system dynamics and assess the impact of such information inaccuracies on SC performance. More specifically, we study the impact of four factors using three SC dynamic performance indicators. The results suggest that demand error has a negative impact (...) on SC performance, which is exacerbated by the magnitude of the error and by low demand variability scenarios. In contrast, demand delay produces a nonlinear behavior in the supply chain response, being influenced by the supply chain configuration. (shrink)

The informed consent process is the legal embodiment of the fundamental right of the individual to make decisions affecting his or her health., and the patient’s permission is a crucial form of respect of freedom and dignity, it becomes extremely important to enhance the patient’s understanding and recall of the information given by the physician. This statement acquires additional weight when the medical treatment proposed can potentially be detrimental or even fatal. This is the case of thalassemia patients pertaining to (...) class 3 of the Pesaro classification where Allogenic hematopoietic stem cell transplantation remains the only potentially curative treatment. Unfortunately, this kind of intervention is burdened by an elevated transplantation-related mortality risk , equal to 30% according to published reports. In thalassemia, the role of the patient in the informed consent process leading up to HSCT has not been fully investigated. This study investigated the hypothesis that information provided by physicians in the medical scenario of HSCT is not fully understood by patients and that misunderstanding and communication biases may affect the clinical decision-making process. (shrink)

A partire dalla produzione saggistica e letteraria di Umberto Eco, l’articolo analizzerà l’immaginario del Medioevo inteso come culla di ogni genere di millenarismo. La trattazione prenderà avvio dal suo saggio Palinsesto su Beato ; tenendo conto dell’originalità della prospettiva strutturalista di Eco, si confronterà l’ultima riedizione di questo scritto con un quadro bibliografico sul ruolo dell’Apocalisse di San Giovanni in seno alla tradizione occidentale. Il primo riferimento sarà la tesi genealogica di Karl Löwith, il quale nel suo Significato e fine (...) della storia affermò che le moderne filosofie della storia rispondono alla stessa ispirazione millenarista della cultura cristiana. Il secondo confronto sarà con uno dei ritratti dell’eresiarca Fra Dolcino; nella fattispecie, sarà considerata la prospettiva del filosofo socialista Antonio Labriola, elaborata a fine Ottocento per distinguere le applicazioni scientifiche del materialismo storico dai suoi fraintendimenti escatologici. Questi due opposti interlocutori condurranno a problematizzare l’interpretazione del millenarismo per come rappresentato da Umberto Eco ne Il nome della rosa. Il romanzo intende infatti l’apocalittica dolciniana come la prefigurazione del terrorismo degli Anni di Piombo? O si tratta di una mera strizzata d’occhio, un gioco con il lettore, il quale è chiamato a non confidare troppo nella potenza simbolica delle analogie? Considering Umberto Eco’s articles and novels, the paper will examine the imaginary of the Middle Age as the cradle of every kind of millenarianism. The analysis will start from Eco’s essay Palinsesto su Beato. Looking at the originality of his structuralist view, I will compare the last editing of this text with a bibliographical framework about the role of the Apocalypse of St. John in the Western tradition. The first reference will be the genealogical thesis of Karl Löwith, who in Meaning in History affirmed that the modern philosophies of history have the same eschatological aim of the Christian culture. The second comparison will be with a portrait of the medieval heresiarch Fra Dolcino. In this case, I will consider the perspective of the socialist philosopher Antonio Labriola, who elaborated it at the end of the XIX Century to distinguish the scientific applications of historical materialism from his eschatological misinterpretations. These two opposite references will drive me to problematize the representation of millenarianism as it was depicted by Umberto Eco in his The Name of the Rose. Indeed, is Dulcinian millenarianism intended by the novel as a prefiguration of the political terrorism in Italy during the Years of Lead? Or is this only a wink, a joking interaction with the reader, who should be careful to rely not on the symbolic strength of analogies? (shrink)

BackgroundEvidence suggests that organizational models that provide care interventions including patient support programs may increase patient adherence to multiple sclerosis therapies by providing tailored symptom management, informational support, psychological and/or social support, lifestyle changes, emotional adjustment, health education, and tailored coaching, thus improving patients' overall quality of life across the disease course.ObjectiveThe main objective of this study was to describe MS patients' self-reported experience of a nurse-led, telephone-based PSP and to explore its potential role in improving disease and therapy management (...) skills.MethodsSurvey data were analyzed from a subset of patients relapsing–remitting MS using interferon beta-1a already registered in the adveva® PSP from three Italian multiple sclerosis centers with a consolidated experience in RRMS disease, treatment management, and PSP programs.ResultsIn total, 244 patient data at baseline were analyzed, of which 115 had a follow-up of at least 6 months. Results from this study provide an early view into the role of this PSP in improving the patients reported overall experience regarding disease management and injectable therapy, thus potentially ameliorating treatment adherence and decreasing health care cost. Moreover, study findings confirm the role of providing a patient-focused support by addressing non-medication-related topics in the PSP consultations. Indeed, patients involved in the adveva® PSP program reported a better psychological status in the follow up as demonstrated by an increased optimism regarding their future, tolerance of disease uncertainty, and their perceived ability to benefit from external help and social support.ConclusionsAs such, it is reasonable to conclude that the involvement in the adveva® PSP and the PSP's assistance in guiding patients on proper treatment self-management techniques is of great value to patients as it might contribute to improving engagement in their health care journey in terms of perceived self-care skills, emotional coping toward the future and the unpredictability of the disease course and their general attitudes toward the injection itself, involving pain tolerance. (shrink)

BackgroundBeta thalassemia major is a severe inherited form of hemolytic anemia that results from ineffective erythropoiesis. Allogenic hematopoietic stem cell transplantation (HSCT) remains the only potentially curative therapy. Unfortunately, the subgroup of adult thalassemia patients with hepatomegaly, portal fibrosis and a history of irregular iron chelation have an elevated risk for transplantation-related mortality that is currently estimated to be about 29 percent.DiscussionThalassemia patients may be faced with a difficult choice: they can either continue conventional transfusion and iron chelation therapy or (...) accept the high mortality risk of HSCT in the hope of obtaining complete recovery.Throughout the decision making process, every effort should be made to sustain and enhance autonomous choice. The concept of conscious consent becomes particularly important. The patient must be made fully aware of the favourable and adverse outcomes of HSCT. Although it is the physician's duty to illustrate the possibility of completely restoring health, considerable emphasis should be put on the adverse effects of the procedure. The physician also needs to decide whether the patient is eligible for HSCT according to the "rule of descending order". The patient must be given full details on self-care and fundamental lifestyle changes and be fully aware that he/she will be partly responsible for the outcome.SummaryOnly if all the aforesaid conditions are satisfied can it be considered reasonable to propose unrelated HSCT as a potential cure for high risk thalassemia patients. (shrink)

Emotion-processing impairment represents a risk factor for the development of somatic illness, affecting negatively both health-related quality of life and disease management in several chronic diseases. The present pilot study aims at investigating the associations between alexithymia and depression, anxiety, and HRQoL in patients with Hashimoto’s thyroiditis ; examining the association between these three psychological conditions together with HRQoL, and thyroid autoantibodies status as well as thyroid echotexture in patients with HT; and comparing the intensity of all these clinical psychological (...) features in patients with HT versus controls. Twenty-one patients with serologically or ultrasonographically verified HT and 16 controls with non-toxic goiter or postsurgical hypothyroidism were recruited for this study. Serum thyrotropin and free thyroxine, as well as thyroid autoantibodies, were assayed. Alexithymia, depression, anxiety, and HRQoL were assessed with Toronto Alexithymia Scale; Beck Depression Inventory, second edition; Hamilton Anxiety Rating Scale; and Health Survey Short-Form 36, respectively. A negative relationship between the difficulty to describe feelings and the cognitive component of depression was found. Besides, patients with seronegative HT had lower somatic anxiety than patients with HT who tested positive. Besides, no statistically significant difference was found between patients with HT and controls with regard to somatic anxiety. The present study suggests the relevance of alexithymia in patients suffering from HT, which may be intertwined with a possible state of underreported depression that is mainly expressed through physical complaints. Promoting the capability to describe and communicate feelings could contribute to psychological elaboration and coping with the disease and, consequently, to the improvement of self-management and perceived HRQoL. (shrink)

The rapid dynamics of COVID-19 calls for quick and effective tracking of virus transmission chains and early detection of outbreaks, especially in the “phase 2” of the pandemic, when lockdown and other restriction measures are progressively withdrawn, in order to avoid or minimize contagion resurgence. For this purpose, contact-tracing apps are being proposed for large scale adoption by many countries. A centralized approach, where data sensed by the app are all sent to a nation-wide server, raises concerns about citizens’ privacy (...) and needlessly strong digital surveillance, thus alerting us to the need to minimize personal data collection and avoiding location tracking. We advocate the conceptual advantage of a decentralized approach, where both contact and location data are collected exclusively in individual citizens’ “personal data stores”, to be shared separately and selectively, voluntarily, only when the citizen has tested positive for COVID-19, and with a privacy preserving level of granularity. This approach better protects the personal sphere of citizens and affords multiple benefits: it allows for detailed information gathering for infected people in a privacy-preserving fashion; and, in turn this enables both contact tracing, and, the early detection of outbreak hotspots on more finely-granulated geographic scale. The decentralized approach is also scalable to large populations, in that only the data of positive patients need be handled at a central level. Our recommendation is two-fold. First to extend existing decentralized architectures with a light touch, in order to manage the collection of location data locally on the device, and allow the user to share spatio-temporal aggregates—if and when they want and for specific aims—with health authorities, for instance. Second, we favour a longer-term pursuit of realizing a Personal Data Store vision, giving users the opportunity to contribute to collective good in the measure they want, enhancing self-awareness, and cultivating collective efforts for rebuilding society. (shrink)

Research on the effects of the COVID-19 pandemic on same-sex relationships is limited. The present study aimed at analyzing the association between the psychophysical impact of the COVID-19 pandemic and same-sex couples’ conflict, also considering the potential mediating effect of internalized sexual stigma. For this purpose, psychophysical challenges and couples’ conflict during the COVID-19 pandemic, ISS, age, biological sex, sexual orientation, relationship duration, religiosity, involvement in lesbian, gay, and bisexual associations, sexual satisfaction, and interpersonal partner violence were assessed in an (...) Italian sample of 232 LGB people engaged in a same-sex relationship. The results indicated that the psychophysical impact of the COVID-19 pandemic was significantly associated with couples’ conflict, and ISS mediated this relationship. Among the covariates considered, only sexual satisfaction was associated with couples’ conflict. The findings suggest that ISS, over and above the adverse effects of the COVID-19 pandemic on psychophysical health, triggered conflict within same-sex relationships. Studying the role of ISS in various relational and social contexts is important, as ISS may have an adverse effect on the mental health of sexual minority people. We recommend that more efforts be made to improve research on the LGB population during the public health response to the COVID-19 emergency, because the paucity of studies underlines the invisibility of this population in many domains, including the domain of romantic relationships. Implications and directions for future research are discussed. (shrink)

O presente artigo trata sobre experiências leitoras motivadas por canções, memórias autobiográficas e comentários publicados em plataformas digitais. Partindo-se do princípio de que a leitura é mais que uma simples atividade de decodificação, defende-se que ao deixar-se ler pelas canções e pela arte o sujeito, involuntariamente, arma-se para produzir sentidos às marcas inscritas e re-inscritas na sua própria história, reinventando-se e gerando novos processos de subjetivação. Os objetivos deste trabalho são: 1. Construir uma compreensão sobre o lugar da canção no (...) cenário artístico brasileiro, bem como sobre a sua capacidade de produzir efeitos nos sujeitos leitores, amparando-se em algumas produções intelectuais reconhecidas no meio acadêmico. 2. Narrar uma experiência de leitura, em que a canção atua como desveladora de demandas afetivas pessoais, geradora de um produto artístico: a série de vídeo Histórias de Maria. 3. Identificar e analisar possíveis leituras sobre as Histórias de Maria, imersas em comentários sobre a respectiva série, publicados nas plataformas digitais. Para efeito didático e metodológico, organiza-se este artigo em três itens: 1) O lugar da canção como suporte de leitura. 2. Experiência subjetiva: leituras de marcas inscritas e reinscritas pela canção. 3. Histórias de Maria: leituras e leitores. Autores como Wisnik, Rossi e Neder Lima, Agamben, Martins e Jouve contribuem para a compreensão do lugar da canção no cenário artístico brasileiro, sua qualidade de objeto biográfico e dispositivo, bem como sua potência em levar o corpo a produzir sentidos para marcas inscritas e reinscritas, através de diversos níveis de leitura. Contribuem, também, para a análise das possíveis leituras imersas nos comentários recolhidos para este trabalho. Por fim, nas considerações finais, conclui-se que toda forma de ler vale a pena. (shrink)

El desafío científico-político de coproducir y proveer "servicios climáticos" en el sudeste de Sudamérica / Cecilia Hidalgo -- Coproducción, ciencia y activismo : empoderamiento epistémico y retórico de activistas seropositivos en la Argentina / Emiliano Marello -- Coproducción en lactancia materna y alimentación del niño pequeño / Pablo Duran -- Coproducción de conocimientos entre especialistas y docentes mediados por una plataforma virtual gubernamental / Marisa Álvarez, Verónica Xhardez y Marcela Pologna -- Conocimiento científico, performatividad e interacción social: compromisos filosófico-sociológicos / (...) María de los A. Martini -- Aportes para un lenguaje de la coproducción / María Laura Martínez -- Ciencia, retórica y semiótica / Robert C. Marafioti -- La cuestión de la agencia en el discurso coproduccionista / Sergio Russo -- Aprendices de brujos : interludios y variaciones en la antropología de la ciencia / Adriana A. Stagnaro -- Una teoría sociológica del conocimiento humano / Florencia Rimoldi -- El conocimiento en la comunicación : aportes pragmatikstas apra la disoluciónd e la imagen clásica del conocimiento científico / Paula Rossi. (shrink)

En este artículo se analizan los límites de la solidaridad desde el descentramiento de los protagonistas mestizos en Limón Reggae, de la costarricense Anacristina Rossi (2007), y Big Banana, del hondureño Roberto Quesada (2000). En la primera novela se representa a los descendientes costarricenses de los migrantes antillanos (jamaiquinos en su mayoría), y en la segunda, a los garífunas hondureños. Mientras Limón Reggae explora una solidaridad de carácter político-estructural, tanto en Costa Rica como en Estados Unidos, así como (...) la posibilidad de una relación amorosa interracial, Big Banana se enfoca en la solidaridad por empatía a través de la relación entre Eduardo y Mairena en territorio estadounidense, problematizando así la posibilidad de reinvención identitaria en ese “tercer espacio”. Ninguno de los dos textos se atreve a presentar una solución simplista u homogénea para la convivencia, por lo que los dos grupos, finalmente, permanecen separados. Ambas recalcan la importancia del lugar de enunciación y, deesta manera, evitan caer en las falacias de las ficciones de solidaridad que se pierden en su propia fantasía de solidaridad. (shrink)

Semantic theories based on a hierarchy of types have prominently been used to defend the possibility of unrestricted quantification. However, they also pose a prima facie problem for it: each quantifier ranges over at most one level of the hierarchy and is therefore not unrestricted. It is difficult to evaluate this problem without a principled account of what it is for a quantifier to be unrestricted. Drawing on an insight of Russell’s about the relationship between quantification and the structure of (...) predication, we offer such an account. We use this account to examine the problem in three different type-theoretic settings, which are increasingly permissive with respect to predication. We conclude that unrestricted quantification is available in all but the most permissive kind of type theory. (shrink)

Recordando a Bachelard a medio siglo de su muerte (2011) -- Filosofia de la relatividad (2011) -- La proliferación de los conceptos de especie en la biología evolucionista (2010).

Plural expressions found in natural languages allow us to talk about many objects simultaneously. Plural logic — a logical system that takes plurals at face value — has seen a surge of interest in recent years. This book explores its broader significance for philosophy, logic, and linguistics. What can plural logic do for us? Are the bold claims made on its behalf correct? After introducing plural logic and its main applications, the book provides a systematic analysis of the relation between (...) this logic and other theoretical frameworks such as set theory, mereology, higher-order logic, and modal logic. The applications of plural logic rely on two assumptions, namely that this logic is ontologically innocent and has great expressive power. These assumptions are shown to be problematic. The result is a more nuanced picture of plural logic's applications than has been given thus far. Questions about the correct logic of plurals play a central role in the final chapters, where traditional plural logic is rejected in favor of a "critical" alternative. The most striking feature of this alternative is that there is no universal plurality. This leads to a novel approach to the relation between the many and the one. In particular, critical plural logic paves the way for an account of sets capable of solving the set-theoretic paradoxes. (shrink)